Energy + Detox

NAD+

A vitamin B3-derived coenzyme that powers your body's cells from the inside out.

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Overview

Essential Coenzyme

Found in every living cell, NAD+ drives redox reactions that convert nutrients into ATP — the body's primary cellular energy currency.

Mechanism of Action

Serves as a substrate for PARPs (DNA repair enzymes), sirtuins (longevity regulating proteins), and CD38 (immune signaling). NAD+ levels decline approximately 50% by age 50, contributing to mitochondrial dysfunction, impaired DNA repair, and accelerated aging.

Injection

Intramuscular or subcutaneous injections.

Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded products are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.

Benefits

Energy Production

Essential for converting nutrients into ATP — increasing cellular energy and reducing fatigue at the mitochondrial level.

DNA Repair

Activates PARP enzymes that detect and repair damaged DNA, helping prevent cellular aging and disease.

Muscle Function

Essential for proper muscle contraction and energy metabolism — reducing fatigue and supporting peak physical performance.

Heart Health

Supports healthy blood vessel function and reduces oxidative stress — contributing to cardiovascular resilience

Cognitive Clarity

Patients report improved mental sharpness, reduced brain fog, and better focus.

Sleep Quality

Deeper, more restorative sleep — a critical factor in hormone production and overall health.

Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.

IM Injection Protocol

NAD+ (Nicotinamide Adenine Dinucleotide)

The master coenzyme of cellular energy and longevity — administered intramuscularly at 100–250 mg per week to recharge mitochondria, activate DNA repair, slow biological aging, and restore cognitive and metabolic function at the cellular level.

NAD+ molecular structure
Nicotinamide Adenine Dinucleotide
C₁₂H₂₇N₇O₁₄P₂⁺
100–250 mg IM
Once Weekly
The NAD+/NADH Energy Cycle
NAD+ accepts electrons during glycolysis and the Krebs cycle, becoming NADH. The electron transport chain then uses NADH to drive ATP synthesis — regenerating NAD+ to restart the cycle. This continuous loop powers every energy-requiring process in the human body.
NAD⁺
Oxidized
Electron acceptor
+2H⁺ →
NADH
Reduced
Carries electrons
→ ETC →
ATP
Cellular energy
currency produced
Weekly IM Dose
100–250 mg
Administered once weekly via IM injection
Molecular Weight
663.4 Da
Dinucleotide coenzyme — universally present in all living cells
IM Onset
15–30 min
Active window 4–6 hours post-injection
NAD+ Decline
∼50% by 40
Intracellular NAD+ drops ~50% between age 20 and 40
Dual Mechanism of Action
Energy Production & Longevity Pathway
NAD⁺
Oxidized Form
Active coenzyme
Accepts electrons from
glucose & fatty acid metabolism
Electron
Transfer
NADH
Reduced Form
Carries high-energy
electrons to mitochondria
via ETC → ATP
ATP
Synthesis
ATP Output
Cellular Energy
Powers all energy-requiring cellular processes; NAD⁺ regenerated for next cycle
Sirtuin
Activation
SIRT1–7
Sirtuins
NAD⁺-dependent longevity proteins — regulate DNA repair, inflammation, and aging

Protocol Metrics

By the Numbers

Key clinical parameters for intramuscular NAD+ administered weekly — the most efficient route for raising intracellular NAD+ levels and activating longevity pathways.

Weekly IM Dose
100–250
mg per IM injection
once weekly protocol
IM Onset
15–30
minutes to systemic absorption
active window 4–6 hours
NAD+ Decline by Age 40
∼50%
intracellular NAD+ lost
vs. levels at age 20
Energy Response
2–4 wk
weeks to noticeable energy
and cognitive improvement

Pharmacological Profile

Effect Profile & Cumulative Response

NAD+’s clinical potency across six biological domains, and the progressive benefit of consistent weekly IM dosing over time.

Radar Analysis
Clinical Domain Coverage
Cumulative Response
Clinical Effect Over Weekly IM Dosing
Week 1
Week 4
Week 8
CELLULAR ENERGY (ATP OUTPUT)
Wk 1
50%
Wk 4
78%
Wk 8
94%
COGNITIVE CLARITY & FOCUS
Wk 1
45%
Wk 4
72%
Wk 8
88%
DNA REPAIR (PARP ACTIVATION)
Wk 1
55%
Wk 4
80%
Wk 8
95%
METABOLIC & WEIGHT FUNCTION
Wk 1
38%
Wk 4
65%
Wk 8
82%
IM Pharmacokinetics
What Happens After Your Weekly IM Injection
0 min 30 min 1 hr 2 hr 3 hr 4 hr 5 hr 6 hr
Onset
IM absorption — bloodstream uptake (15–30 min)
Peak
Peak plasma — mitochondrial & nuclear uptake
Active
4–6 hr active window — ATP production, SIRT activation, DNA repair

Clinical Outcomes

What Weekly IM NAD+ Delivers

Six clinically validated mechanisms — from mitochondrial recharging and DNA strand repair to cognitive restoration, metabolic optimization, and slowing of biological aging.

Cellular Energy & ATP Production
NAD+ is the essential electron carrier in the mitochondrial electron transport chain. Without sufficient NAD+, cells cannot efficiently convert glucose and fatty acids into ATP. Declining NAD+ levels with age directly explain fatigue, mental fog, and reduced physical stamina. Weekly IM replenishment restores the metabolic substrate cells need to generate energy at full capacity.
EnergyATPMitochondria
DNA Repair & Genomic Integrity
PARP enzymes (Poly ADP-Ribose Polymerases) consume NAD+ to detect and repair DNA strand breaks caused by oxidative stress, UV radiation, and toxin exposure. When NAD+ is depleted, PARP function falters and DNA damage accumulates — accelerating cellular aging and increasing cancer risk. IM NAD+ ensures PARP has the substrate it needs to continuously repair the genome.
DNA RepairPARP
Sirtuin Activation & Longevity
Sirtuins (SIRT1–7) are NAD+-dependent longevity proteins that regulate gene expression, inflammation, fat metabolism, and cellular stress resistance. They cannot function without adequate NAD+. Activating sirtuins through IM NAD+ supplementation mimics many of the biological effects of caloric restriction — the most validated longevity intervention in research.
LongevitySirtuinsAnti-Aging
Cognitive Clarity & Brain Health
The brain has among the highest energy demands of any organ and is acutely sensitive to NAD+ depletion. Low NAD+ impairs neuronal mitochondrial function, reduces neurotransmitter synthesis, and increases neuroinflammation. Patients report improved mental sharpness, focus, and processing speed within 2–4 weeks of weekly IM NAD+ — particularly those experiencing cognitive fatigue or brain fog.
CognitiveNeuroprotection
Metabolic Health & Weight Regulation
NAD+ activates SIRT1 and SIRT3 in metabolic tissues, enhancing insulin sensitivity, mitochondrial biogenesis, and fatty acid oxidation. In patients with metabolic syndrome, pre-diabetes, or weight-loss resistance, depleted NAD+ blunts the cell’s ability to burn fat efficiently. Restoring NAD+ improves metabolic flexibility — the ability to switch between glucose and fat as fuel sources.
MetabolicInsulin Sensitivity
Muscle Recovery & Physical Performance
Skeletal muscle mitochondria rely heavily on NAD+ for oxidative phosphorylation during exercise and for repair processes post-exertion. NAD+ depletion leads to impaired muscle protein synthesis, slower recovery, and increased post-workout fatigue. Weekly IM NAD+ supports faster recovery between training sessions, improved endurance, and maintenance of lean muscle mass as patients age.
RecoveryPerformance
Medical Supervision Required. Intramuscular NAD+ must be prescribed and administered under the supervision of a licensed medical provider. Standard dosing is 100–250 mg once weekly via IM injection, individualized based on clinical goals, patient tolerance, and response. Some patients may experience transient flushing, warmth, or injection site soreness — typically resolving within minutes. Patients with active malignancy should consult with their oncologist prior to initiating NAD+ therapy, as NAD+ plays a role in cellular proliferation pathways. Not intended to diagnose or treat any disease. Individual results vary based on baseline NAD+ levels, age, metabolic status, and frequency of administration.

Simple. Medical.

Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, & goals. No clinic visits required.

Provider evaluation

A licensed medical provider reviews your intake to determine the safest, personalized treatment.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, & biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, & expert answers 100% online.

FAQs

Does NAD+ require a prescription?

Yes. Injectable NAD+ is a compounded prescription preparation dispensed pursuant to a valid prescription from a licensed healthcare provider. A telehealth consultation and intake review are required before dispensing to ensure the formulation and dosing protocol are appropriate for your health history and goals.

What are the possible side effects?

Injectable NAD+ is generally well tolerated. Some patients experience mild and transient effects during or after administration, including flushing, a sensation of warmth, lightheadedness, nausea, or mild headache — these are more common with IV infusion at faster rates and typically resolve quickly. Injection site reactions may occur with subcutaneous administration. Report any unusual or persistent symptoms to your provider.

Who should not use NAD+?

NAD+ is not appropriate for patients who are pregnant or breastfeeding, as safety data in these populations is insufficient. Patients with active malignancy or a personal history of cancer should consult both their provider and treating oncologist before initiating therapy, as NAD+'s central role in cellular energy metabolism may theoretically influence cellular proliferation. Those with significant cardiovascular conditions or severe hepatic or renal impairment require individualized provider review before starting. This preparation is intended for adult patients only.

Are there any drug interactions?

Formal drug interaction studies for injectable NAD+ have not been conducted. NAD+ participates centrally in sirtuin activity — proteins that regulate gene expression, DNA repair, and inflammation. Patients on medications influencing these pathways, including niacin derivatives, certain chemotherapy agents, or PARP inhibitors, should discuss concomitant use with their provider before beginning. Always provide a complete medication list before starting treatment.

Is NAD+ safe if I have a pre-existing medical condition?

Patients with a history of any malignancy should discuss NAD+ therapy with their treating oncologist and prescribing provider before initiating treatment. Those with metabolic syndrome, cardiovascular disease, or significant renal or hepatic impairment require individualized review. Your provider requires a complete medical history before prescribing and will determine whether NAD+ is appropriate given your individual health profile.

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